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When designing a game environment, there are a number of things to consider:
Species - What is available to the players for character generation? Also,
there may be species that are not for the players, but make excellent
adversaries. How many points are available for character generation in the
point system?
Gear - What weapons and equipment are available? How much does each
item cost?
Money System - Gold? Dollars?
Healing - What is the method of healing? Are quick heals available?
Magic - Does the setting support magic or mentalist abilities?